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Research Institute for Bioscience and Biotechnology

Recent Updates
Dr. Paudel participated in a workshop on Current Trends in Chemical and Pharmaceutical Sciences, and Related Discipline, Phitsanulok Province, Thailand.                                                                                                                                                                                                           Dr. Bijay Singh participated in 27th TWAS General Meeting in Kigali, Rwanda                                                                                                                                                                                                           Dr. Bijay Singh wins Atta-ur-Rahman Prize 2016                                                                                                                                                                                                           Dr. Babita Paudel received Lunkaran Das Nawa Prativa (Emerging Talent) 2073                                                                                                                                                                                                           Dr. Sushila Maharjan participated in “TWAS Research Grants Conference – Shaping Careers in Science”                                                                                                                                                                                                           Dr. Paudel presented her work on Nepalese Lichens at Laos                                                                                                                                                                                                           Mr. Rajbhandari received travel award to participate in 2015 Food Biotechnology Training Course for Developing countries.                                                                                                                                                                                                           Dr. Maharjan awarded Elsevier Foundation Award 2016                                                                                                                                                                                                           Mr. Rajbhandari invited as guest of honor to attend International Energy Globe Award held in Tehran.                                                                                                                                                                                                           Dr. Bhattarai has been accepted for KOPRI Asian Polar Science Fellowship Program 2015.                                                                                                                                                                                                           President and Vice President presented in Asian Congress of Biotechnology (ACB – 2015).                                                                                                                                                                                                           Mr. Rajbhandari participated in international conference on organic farming (ICOF2015)                                                                                                                                                                                                           Mr. Rajbhandari participated in opening ceremony and workshop of KOICA-APP program                                                                                                                                                                                                           National Energy Globe Award 2015                                                                                                                                                                                                           Mr. Rajbhandari presented in seoul international conference on engineering and applied science (SICEAS-2015)                                                                                                                                                                                                           Mr. Shrestha presented at national conference on biotechnology                                                                                                                                                                                                           Dr. Bhattarai presented his research paper at national conference on biotechnology                                                                                                                                                                                                           Mr. Rajbhandari presented in TSB international forum                                                                                                                                                                                                           Prof. Lamichhane presented in TSB international forum                                                                                                                                                                                                           Mr. Rajbhandari presented at Mahidol University                                                                                                                                                                                                           Prof. Lamichhane presented at Mahidol University                                                                                                                                                                                                           “Nepal @ TOULOUSE”                                                                                                                                                                                                           MoU between RIBB and INP Toulouse                                                                                                                                                                                                           MoU between RIBB and iBR                                                                                                                                                                                                          

Alexander von Humboldt Foundation Funded Research Projects


Project Title: Exploration of novel antibiotics, antioxidants and anticancer compounds from micro-organisms (bacteria, fungi, lichens) collected from extreme environments of mountainous regions of Nepal.



Link: https://www.humboldt-foundation.de/web/1600.html



Project Introduction: Microorganisms (bacteria, fungi, lichen) are well known resources for various natural metabolites some of which are already dominant in pharmacological application such as penicillin. Several Streptomyces and Actinomyces species are reported to produce antibiotics, antifungal and anticancer metabolites. Similarly, lichens are potential sources of unique types of metabolites with various biological activities especially antioxidant, anticancer and antibiotics. The exploration of bioactive metabolites producing micro-organisms from mountainous regions of Nepal is yet to be done systematically. Due to extreme environment and scientifically untouched geographic region, a number of novel micro-organisms with potential biological activities are believed to be explored during this research project. Micro-organisms will be isolated from soil, water, plants and rocks samples. Antibiotic activities will be evaluated for each isolated micro-organisms against various pathogenic clinical micro-organisms. Micro-organisms identification will be carried out by analyzing 16S rDNA sequence analysis. In addition, we will establish a cryopreservation based culture collection of such bioactive metabolites producing micro-organisms so that other scientists can perform further research works in future. Biologically active natural compounds will be isolated and characterized from each biological activity showing micro-organisms. Various chromatography techniques such as thin layer chromatography (TLC), mild pressure liquid chromatography (MPLC), column chromatography, and High pressure liquid chromatography (HPLC) will be applied as per suitability and necessity to purify natural compounds from the crude extracts. The purified compounds will be structurally identified by analyzing spectroscopic data obtained from UV, IR, 1D and 2D NMR experiments. The quantitative analysis of biological activities (antibiotic, antioxidant, anticancer, antifungal, and anti-diabetic) of identified natural compounds will be conducted and compared with commercial standards by using standard protocols.


Message From President

Welcome to the homepage of Research Institute for Bioscience and Biotechnology (RIBB). We are a young biotechnology based research institute thriving to work together with experts and young scientists of Nepal in the different field of biotechnology basically on Natural Products & Biodiversity, Pharmaceutical and Food Science and Bioenergy. Since our establishment in 2011, we have collaborated with scientists from around the world and within Nepal to provide a platform to conduct research of highest quality in Nepal.…

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